- Cerebral ischemic brain injury (global and focal cerebral ischemia). Neuropathological mechanisms of stroke.
- Neurodegeneration and neuroprotection studies in relevant animal models of brain damage.
- Neuroregeneration and neurorestorative strategies for stroke.
- Cyclooxygenases, prostaglandins, prostanoid receptors, neuroinflammation.
- Matrix metalloproteinases in neuroinflammation and cerebral ischemia.
- Excitotoxicity, neuronal damage induced by oxidative stress, neuronal apoptosis.
- Signal transduction pathways regulating the production of
pro-inflammatory mediators (e.g., prostaglandin E2, IL-1b, TNF-a) after
ischemic brain injury.
- Natural antioxidant compounds and vitamins, free radical biology, antioxidant enzymes.