This is my personal website. It is intended to publish my research interests, scientific publications, CV and links to PDFs of papers published by our research group.

 

LIST OF PUBLICATIONS 

(Click on the PDF link to get the digital version of the original article)

 

  1. Candelario-Jalil E, Yang Y, Rosenberg GA. Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia. Neuroscience 2009; 158(3):983-994.  PDF
  2. Sood RR, Yang Y, Taheri S, Candelario-Jalil E, Estrada EY, Walker EJ, Thompson J, Rosenberg GA. Increased Apparent Diffusion Coefficients on MRI linked with matrix metalloproteinases and edema in white matter after bilateral carotid artery occlusion in rats. Journal of Cerebral Blood Flow and Metabolism 2009; 29(2):308-316. PDF
  3. Navarrete CM, Fiebich BL, de Vinuesa AG, Hess S, de Oliveira AC, Candelario-Jalil E, Caballero FJ, Calzado MA, Muñoz E. Opposite effects of anandamide and N-arachidonoyl dopamine in the regulation of prostaglandin E2 and 8-iso-PGF2α formation in primary glial cells. Journal of Neurochemistry 2009; 109(2): 452-464. PDF
  4. Candelario-Jalil E, Fiebich BL. Cyclooxygenase inhibition in ischemic brain injury. Current Pharmaceutical Design 2008; 14(14): 1401-1418. PDF
  5. Candelario-Jalil E, Muñoz E, Fiebich BL. Detrimental effects of tropisetron on permanent ischemic stroke in the rat. BMC Neuroscience 2008; 9:19. PDF
  6. Candelario-Jalil E. Nimesulide as a promising neuroprotectant in brain ischemia: new experimental evidences. Pharmacological Research 2008; 57(4): 266-273. PDF
  7. de Oliveira AC, Candelario-Jalil E, Bhatia HS, Lieb K, Hull M, Fiebich BL. Regulation of prostaglandin E2 synthase expression in activated primary rat microglia: evidence for uncoupled regulation of mPGES-1 and COX-2. Glia 2008; 56(8): 844-855. PDF
  8. Bhatia HS, Candelario-Jalil E (co-first author), de Oliveira C, Olajide OA, Martinez-Sanchez G, Fiebich BL. Mangiferin inhibits cyclooxygenase-2 expression and prostaglandin E2 production in activated rat microglial cells. Archives of Biochemistry and Biophysics 2008; 477(2):253-258. PDF
  9. Seidel MF, Fiebich BL, Ulrich-Merzenich G, Candelario-Jalil E, Koch FW, Vetter H. Serotonin mediates PGE2 overexpression through 5-HT(2A) and 5-HT(3) receptor subtypes in serum-free tissue culture of macrophage-like synovial cells. Rheumatology International 2008; 28(10):1017-1022. PDF
  10. Ajamieh HH, Candelario-Jalil E, Fernández OS, Gerbes AL. Ischaemic and pharmacological preconditionings protect liver via adenosine and redox status following hepatic ischaemia-reperfusion in rats. Clinical Science (London) 2008; 115(2): 69-77.  PDF
  11. Sood RR, Taheri S, Candelario-Jalil E, Estrada EY, Rosenberg GA. Early beneficial effect of matrix metalloproteinase inhibition on blood-brain barrier permeability as measured by magnetic resonance imaging countered by impaired long-term recovery after stroke in rat brain. Journal of Cerebral Blood Flow and Metabolism 2008; 28(2): 431-438. PDF
  12. Candelario-Jalil E, Taheri S, Yang Y, Sood R, Grossetete M, Estrada EY, Fiebich BL, Rosenberg GA. Cyclooxygenase Inhibition Limits Blood-Brain Barrier Disruption following Intracerebral Injection of Tumor Necrosis Factor-a in the Rat. Journal of Pharmacology and Experimental Therapeutics 2007; 323(2): 488-498. PDF
  13. Candelario-Jalil E, de Oliveira AC, Graf S, Bhatia HS, Hull M, Muñoz E, Fiebich BL. Resveratrol potently reduces prostaglandin E2 production and free radical formation in lipopolysaccharide-activated primary rat microglia. Journal of Neuroinflammation 2007; 4(1):25. PDF
  14. Candelario-Jalil E, González-Falcón A, García-Cabrera M, León OS, Fiebich BL. Post-ischemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischemia in rats. Journal of Neurochemistry 2007; 100(4): 1108-1120. PDF
  15. Candelario-Jalil E. Cyclooxygenase-2 regulation of brain lipid composition. Future Lipidology 2007 Aug; 2(4): 399-402. PDF
  16. Candelario-Jalil E, Akundi RS, Bhatia HS, Lieb K, Appel K, Muñoz E, Hull M, Fiebich BL. Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production. Journal of Neuroimmunology 2006; 174(1-2): 39-51. PDF
  17. Waschbisch A, Fiebich BL, Akundi RS, Schmitz ML, Hoozemans JJ, Candelario-Jalil E, Virtainen N, Veerhuis R, Slawik H, Yrjanheikki J, Hull M. Interleukin-1 beta-induced expression of the prostaglandin E-receptor subtype EP3 in U373 astrocytoma cells depends on protein kinase C and nuclear factor-kappaB. Journal of Neurochemistry 2006; 96(3): 680-693. PDF
  18. Fiebich BL, Candelario-Jalil E (co-first author), Mantovani M, Heinzmann M, Akundi RS, Hull M, Knorle R, Schnierle P, Finkenzeller G, Aicher B. Modulation of catecholamine release from rat striatal slices by the fixed combination of aspirin, paracetamol and caffeine. Pharmacological Research 2006; 53(4): 391-396. PDF
  19. Fiebich BL, Valente P, Ferrer-Montiel A, Candelario-Jalil E, Menthe J, Luecker P. Effects of coffees before and after special treatment procedure on cell membrane potentials in stomach cells. Methods and Findings in Experimental and Clinical Pharmacology 2006; 28(6): 369-372.
  20. Candelario-Jalil E, Mhadu NH, González-Falcón A, García-Cabrera M, Muñoz E, León S, Fiebich BL. Effects of the cyclooxygenase-2 inhibitor nimesulide on cerebral infarction and neurological deficits induced by permanent middle cerebral artery occlusion in the rat. Journal of Neuroinflammation 2005; 2(1): 3. PDF
  21. Candelario-Jalil E, Slawik H, Ridelis I, Waschbisch A, Akundi RS, Hüll M, Fiebich BL. Regional distribution of the prostaglandin E2 receptor EP1 in the rat brain: accumulation in Purkinje cells of the cerebellum. Journal of Molecular Neuroscience 2005; 27(3): 303-10. PDF
  22. Akundi RS, Candelario-Jalil E, Hess S, Hüll M, Lieb K, Gebicke-Haerter PJ, Fiebich BL. Signal transduction pathways regulating cyclooxygenase-2 in lipopolysaccharide-activated primary rat microglia. Glia 2005; 51(3): 199-208. PDF
  23. Lieb K, Biersack L, Waschbisch A, Orlikowski S, Akundi RS, Candelario-Jalil E, Hüll M, Fiebich BL. Serotonin via 5-HT7 receptors activates p38 MAP kinase and protein kinase C epsilon resulting in interleukin-6 synthesis in human U373 MG astrocytoma cells. Journal of Neurochemistry 2005; 93(3): 549-559. PDF
  24. de la Vega L, Muñoz E, Calzado MA, Lieb K, Candelario-Jalil E, Gescheidmeir H, Färber L, Mueller W, Stratz T, Fiebich BL. The 5-HT3 receptor antagonist tropisetron inhibits T cell activation by targeting the calcineurin pathway. Biochemical Pharmacology 2005; 70(3): 369-380. PDF
  25. Martínez-Sánchez G, Al-Dalain SM, Menéndez S, Re L, Giuliani A, Candelario-Jalil E, Alvarez H, Fernández-Montequin JI, León OS. Therapeutic efficacy of ozone in patients with diabetic foot. European Journal of Pharmacology 2005; 523(1-3): 151-161. PDF
  26. Candelario-Jalil E, González-Falcón A, García-Cabrera M, León OS, Fiebich BL. Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat. Brain Research 2004; 1007(1-2): 98-108.  PDF
  27. Ajamieh HH, Menéndez S, Martínez-Sánchez G, Candelario-Jalil E, Re L, Giuliani A, León OS. Effects of ozone oxidative preconditioning on nitric oxide generation and cellular redox balance in a rat model of hepatic ischaemia-reperfusion. Liver International 2004; 24(1): 55-62. PDF
  28. Fiebich BL, Akundi RS, Seidel M, Geyer V, Haus U, Müller W, Stratz T, Candelario-Jalil E. Expression of 5-HT3A receptors in cells of the immune system. Scandinavian Journal of Rheumatology 2004; 33: 9-11. PDF
  29. Fiebich BL, Akundi RS, Lieb K, Candelario-Jalil E, Gmeiner D, Haus U, Müller W, Stratz T, Munoz E. Anti-inflammatory effects of 5-HT3 receptor antagonists in lipopolysaccharide-stimulated primary human monocytes. Scandinavian Journal of Rheumatology 2004; 33: 28-32. PDF
  30. Seidel MF, Ulrich-Merzenich G, Fiebich BL, Candelario-Jalil E, Koch FW, Vetter H. Tropisetron inhibits serotonin-induced PGE2 release from macrophage-like synovial cells in serum-free tissue culture. Scandinavian Journal of Rheumatology 2004; 33: 33.  PDF
  31. Candelario-Jalil E, González-Falcón A, García-Cabrera M, Álvarez D, Al-Dalain S, Martínez G, León OS, Springer JE. Assessment of the relative contribution of COX-1 and COX-2 isoforms to ischemia-induced oxidative damage and neurodegeneration following transient global cerebral ischemia. Journal of Neurochemistry 2003; 86(3): 545-555. PDF
  32. Candelario-Jalil E, Alvarez D, Merino N, León OS. Delayed treatment with nimesulide reduces measures of oxidative stress following global ischemic brain injury in gerbils. Neuroscience Research 2003; 47(2): 245-253. PDF
  33. Candelario-Jalil E, León OS. Effects of nimesulide on kainate-induced in vitro oxidative damage in rat brain homogenates. BMC Pharmacology 2003; 3(1): 7. PDF
  34. González-Falcón A; Candelario-Jalil E (co-first author), García-Cabrera M, León OS. Effects of pyruvate administration on infarct volume and neurological deficits following permanent focal cerebral ischemia in rats. Brain Research 2003; 990(1-2): 1-7. PDF
  35. Candelario-Jalil E, Álvarez D, García-Cabrera M, González-Falcón A, Martínez G, Merino N, Giuliani A, León OS. Neuroprotective efficacy of nimesulide against hippocampal neuronal damage following transient forebrain ischemia. European Journal of Pharmacology 2002; 453(2-3): 189-195. PDF
  36. Candelario-Jalil E, Alvarez D, Castañeda JM, Al-Dalain SM, Martínez G, Merino N, León OS. The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils. Brain Research 2002; 927(2): 212-215. PDF
  37. Ajamieh H, Merino N, Candelario-Jalil E, Menéndez S, Martínez-Sánchez G, Re L, Giuliani A, León OS. Similar protective effect of ischaemic and ozone oxidative preconditionings in liver ischaemia/reperfusion injury. Pharmacological Research 2002; 45(4): 333-339.  PDF
  38. Candelario-Jalil E, Mhadu NH, Al-Dalain SM, Martínez G, León OS. Time course of oxidative damage in different brain regions following transient cerebral ischemia in gerbils. Neuroscience Research 2001; 41(3): 233-241. PDF
  39. Candelario-Jalil E, Al-Dalain SM, Castillo R, Martínez G, León OS. Selective vulnerability to kainate-induced oxidative damage in different rat brain regions. Journal of Applied Toxicology 2001; 21(5): 403-407. PDF
  40. Martínez G, Candelario-Jalil E (co-first author), Giuliani A, León OS, Sam S, Delgado R, Núñez Sellés AJ. Mangifera indica L. extract (QF808) reduces ischaemia-induced neuronal loss and oxidative damage in the gerbil brain. Free Radical Research 2001; 35(5): 465-73. PDF
  41. Candelario-Jalil E, Al-Dalain SM, León OS, Menéndez S, Pérez-Davison G, Merino N, Sam S, Ajamieh HH. Oxidative preconditioning affords protection against carbon tetrachloride-induced glycogen depletion and oxidative stress in rats. Journal of Applied Toxicology 2001; 21(4): 297-301. PDF
  42. Al-Dalain SM, Martínez G, Candelario-Jalil E, Menéndez S, Re L, Giuliani A, León OS. Ozone treatment reduces markers of oxidative and endothelial damage in an experimental diabetes model in rats. Pharmacological Research 2001; 44(5): 391-396. PDF
  43. Candelario-Jalil E, Ajamieh HH, Sam S, Martínez G, León OS. Nimesulide limits kainate-induced oxidative damage in the rat hippocampus. European Journal of Pharmacology 2000; 390(3): 295-298. PDF
  44. Peralta C, León OS, Xaus C, Prats N, Candelario-Jalil E, Planell ES, Puig-Parellada P, Gelpí E, Roselló-Catafau J. Protective effect of ozone treatment on the injury associated with hepatic ischemia-reperfusion: antioxidant/prooxidant balance. Free Radical Research 1999; 31(3): 191-196. PDF