This is my personal website. It is intended to publish my research interests, scientific publications, CV and links to PDFs of papers published by our research group.
LIST OF PUBLICATIONS
(Digital version of the original articles is available by clicking the PDF link -- See below)
Candelario-Jalil E, Munoz E, Fiebich BL. Detrimental effects of tropisetron on permanent ischemic stroke in the rat. BMC Neurosci. 2008 (in press). --- PDF
Sood RR, Taheri S, Candelario-Jalil E, Estrada EY,
Candelario-Jalil E, de Oliveira AC, Graf S, Bhatia HS, Hull M, Munoz E, Fiebich BL. Resveratrol potently reduces prostaglandin E2 production and free radical formation in lipopolysaccharide-activated primary rat microglia. J Neuroinflammation 2007 Oct; 4: 25. --- PDF
Candelario-Jalil E, Taheri S, Yang Y, Sood R, Grossetete M, Estrada EY, Fiebich BL, Rosenberg GA. Cyclooxygenase Inhibition Limits Blood-Brain Barrier Disruption following Intracerebral Injection of Tumor Necrosis Factor-alpha in the Rat. J. Pharmacol. Exp. Ther. 2007 Nov; 323(2): 488-498. --- PDF
Candelario-Jalil E. Cyclooxygenase-2 regulation of brain lipid composition. Future Lipidology 2007 Aug; 2(4): 399-402. --- PDF
Candelario-Jalil E, González-Falcón A, García-Cabrera M, León OS, Fiebich BL. Post-ischemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischemia in rats. J Neurochem 2007 Feb; 100(4): 1108-1120. --- PDF
Candelario-Jalil E, Akundi RS, Bhatia HS, Lieb K, Appel K, Munoz E, Hull M, Fiebich BL. Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E(2) production. J Neuroimmunol 2006 May;174 (1-2): 39-51. PDF
Fiebich BL, Candelario-Jalil E, Mantovani M, Heinzmann M, Akundi RS, Hull M, Knorle R, Schnierle P, Finkenzeller G, Aicher B. Modulation of catecholamine release from rat striatal slices by the fixed combination of aspirin, paracetamol and caffeine. Pharmacol Res. 2006 Apr;53(4):391-6. --- PDF
Waschbisch A, Fiebich BL, Akundi RS, Schmitz ML, Hoozemans JJ, Candelario-Jalil E, Virtainen N, Veerhuis R, Slawik H, Yrjanheikki J, Hull M. Interleukin-1 beta-induced expression of the prostaglandin E-receptor subtype EP3 in U373 astrocytoma cells depends on protein kinase C and nuclear factor-kappaB. J Neurochem. 2006 Feb;96(3):680-93. --- PDF
Candelario-Jalil E, Slawik H, Ridelis I, Waschbisch A, Akundi RS, Hull M, Fiebich BL. Regional distribution of the prostaglandin E2 receptor EP1 in the rat brain: accumulation in Purkinje cells of the cerebellum. J Mol Neurosci. 2005;27(3):303-10. --- PDF
Martinez-Sanchez G, Al-Dalain SM, Menendez S, Re L, Giuliani A, Candelario-Jalil E, Alvarez H, Fernandez-Montequin JI, Leon OS. Therapeutic efficacy of ozone in patients with diabetic foot. Eur J Pharmacol. 2005 Oct 31;523(1-3):151-61. --- PDF
Vega L de L, Munoz E, Calzado MA, Lieb K, Candelario-Jalil E, Gschaidmeir H, Farber L, Mueller W, Stratz T, Fiebich BL. The 5-HT3 receptor antagonist tropisetron inhibits T cell activation by targeting the calcineurin pathway. Biochem Pharmacol. 2005 Aug 1;70(3):369-80. --- PDF
Lieb K, Biersack L, Waschbisch A, Orlikowski S, Akundi RS, Candelario-Jalil E, Hull M, Fiebich BL. Serotonin via 5-HT7 receptors activates p38 mitogen-activated protein kinase and protein kinase C epsilon resulting in interleukin-6 synthesis in human U373 MG astrocytoma cells. J Neurochem. 2005 May; 93(3): 549-59. --- PDF
Akundi RS, Candelario-Jalil E, Hess S, Hull M, Lieb K, Gebicke-Haerter PJ, Fiebich BL. Signal transduction pathways regulating cyclooxygenase-2 in lipopolysaccharide-activated primary rat microglia. Glia. 2005 Aug 15;51(3):199-208. --- PDF
Candelario-Jalil E, Mhadu NH, Gonzalez-Falcon A, Garcia-Cabrera M, Munoz E, Leon OS, Fiebich BL. Effects of the cyclooxygenase-2 inhibitor nimesulide on cerebral infarction and neurological deficits induced by permanent middle cerebral artery occlusion in the rat. J Neuroinflammation. 2005 Jan 18;2(1):3. --- PDF
Seide MF, Ulrich-Merzenich G, Fiebich B, Candelario-Jalil E, Koch FW, Vetter H. Tropisetron inhibits serotonin-induced PGE2 release from macrophage-like synovial cells in serum-free tissue culture. Scand J Rheumatol Suppl. 2004;(119): 33. --- PDF
Fiebich BL, Akundi RS, Lieb K, Candelario-Jalil E, Gmeiner D, Haus U, Muller W, Stratz T, Munoz E. Antiinflammatory effects of 5-HT3 receptor antagonists in lipopolysaccharide-stimulated primary human monocytes. Scand J Rheumatol Suppl. 2004;(119): 28-32. --- PDF
Fiebich BL, Akundi RS, Seidel M, Geyer V, Haus U, Muller W, Stratz T, Candelario-Jalil E. Expression of 5-HT3A receptors in cells of the immune system. Scand J Rheumatol Suppl. 2004;(119): 9-11. --- PDF
Ajamieh HH, Menendez S, Martinez-Sanchez G, Candelario-Jalil E, Re L, Giuliani A, Fernandez OS. Effects of ozone oxidative preconditioning on nitric oxide generation and cellular redox balance in a rat model of hepatic ischaemia-reperfusion. Liver Int. 2004 Feb;24(1):55-62. --- PDF
Candelario-Jalil E, Gonzalez-Falcon A, Garcia-Cabrera M, Leon OS, Fiebich BL. Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat. Brain Res. 2004 May 8;1007(1-2):98-108. --- PDF
Gonzalez-Falcon A, Candelario-Jalil E, Garcia-Cabrera M, Leon OS. Effects of pyruvate administration on infarct volume and neurological deficits following permanent focal cerebral ischemia in rats. Brain Res. 2003 Nov 14;990(1-2):1-7. --- PDF
Candelario-Jalil E, Alvarez D, Merino N, Leon OS. Delayed treatment with nimesulide reduces measures of oxidative stress following global ischemic brain injury in gerbils. Neurosci Res. 2003 Oct;47(2):245-53. --- PDF
Candelario-Jalil E, Gonzalez-Falcon A, Garcia-Cabrera M, Alvarez D, Al-Dalain S, Martinez G, Leon OS, Springer JE. Assessment of the relative contribution of COX-1 and COX-2 isoforms to ischemia-induced oxidative damage and neurodegeneration following transient global cerebral ischemia. J Neurochem. 2003 Aug;86(3):545-55. PDF
Candelario-Jalil E, Sonia Leon O. Effects of nimesulide on kainate-induced in vitro oxidative damage in rat brain homogenates. BMC Pharmacol. 2003 Jun 14;3:7 --- PDF
Candelario-Jalil E, Alvarez D, Gonzalez-Falcon A, Garcia-Cabrera M, Martinez-Sanchez G, Merino N, Giuliani A, Leon OS. Neuroprotective efficacy of nimesulide against hippocampal neuronal damage following transient forebrain ischemia. Eur J Pharmacol. 2002 Oct 25;453(2-3):189-95. --- PDF
Ajamieh H, Merino N, Candelario-Jalil E, Menendez S, Martinez-Sanchez G, Re L, Giuliani A, Leon OS. Similar protective effect of ischaemic and ozone oxidative preconditionings in liver ischaemia/reperfusion injury. Pharmacol Res. 2002 Apr;45(4):333-9. --- PDF
Candelario-Jalil E, Alvarez D, Castaneda JM, Al-Dalain SM, Martinez-Sanchez G, Merino N, Leon OS. The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils. Brain Res. 2002 Feb 15;927(2):212-5. --- PDF
Martinez Sanchez G, Candelario-Jalil E, Giuliani A, Leon OS, Sam S, Delgado R, Nunez Selles AJ. Mangifera indica L. extract (QF808) reduces ischaemia-induced neuronal loss and oxidative damage in the gerbil brain. Free Radic Res. 2001 Nov; 35(5): 465-73. --- PDF
Candelario-Jalil E, Al-Dalain SM, Castillo R, Martinez G, Fernandez OS. Selective vulnerability to kainate-induced oxidative damage in different rat brain regions. J Appl Toxicol. 2001 Sep-Oct;21(5):403-7. PDF
Al-Dalain SM, Martinez G, Candelario-Jalil E, Menendez S, Re L, Giuliani A, Leon OS. Ozone treatment reduces markers of oxidative and endothelial damage in an experimental diabetes model in rats. Pharmacol Res. 2001 Nov; 44(5):391-6. --- PDF
Candelario-Jalil E, Mhadu NH, Al-Dalain SM, Martinez G, Leon OS. Time course of oxidative damage in different brain regions following transient cerebral ischemia in gerbils. Neurosci Res. 2001 Nov; 41(3): 233-41. --- PDF
Candelario-Jalil E, Mohammed-Al-Dalain S, Fernandez OS, Menendez S, Perez-Davison G, Merino N, Sam S, Ajamieh HH. Oxidative preconditioning affords protection against carbon tetrachloride-induced glycogen depletion and oxidative stress in rats. J Appl Toxicol. 2001 Jul-Aug;21(4):297-301. --- PDF
Candelario-Jalil E, Ajamieh HH, Sam S, Martinez G, Leon Fernandez OS. Nimesulide limits kainate-induced oxidative damage in the rat hippocampus. Eur J Pharmacol. 2000 Mar 3; 390(3):295-8. --- PDF
Peralta C, Leon OS, Xaus C, Prats N, Candelario-Jalil E, Planell ES, Puig-Parellada P, Gelpi E, Rosello-Catafau J. Protective effect of ozone treatment on the injury associated with hepatic ischemia-reperfusion: antioxidant-prooxidant balance. Free Radic Res. 1999; 31 (3): 191-196. --- PDF